ביוקונברג’נס
ביוקונברג’נס הינו תחום מחקר מדעי בין-תחומי חדש המשלב בתוכו ביוטכנולוגיה, כימיה, הנדסה, ומדעי המחשב. תחום זה נותן מענה לאתגרים מורכבים בתחום הבריאות, הבר-קיימא, החקלאות ועוד. הוא מאפשר חדשניות ברפואה מותאמת אישית, טיפולים רגנרטיביים, אבחנות מתקדמות וחומרים מושראים מהביולוגיה. לביוקונברג’נס יש את היכולת לשנות את הדרך שבה אנחנו מונעים, מנבאים ומטפלים במחלות, ובכלל לשפר את איכות החיים של מיליוני אנשים ברחבי העולם. חוקרי BINA מעורבים במגוון היבטים הקשורים לביוקונברג’נס, כולל:
- ביוצ’יפים
- חיישנים ביולוגיים
- איברים אנושיים על צ’יפים
- ממשקים של נוירון-צ’יפ ותא-צ’יפ
- מכשירים מיקרו-אופטיים ואלקטרוניים
- מיקרופלואידיקה ומעבדה על צ'יפ
- חיישנים אלקטרוכימיים
Researchers
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Optical and Acoustical Neuroimaging Lab
Our neuroengineering research focuses on developing advanced acoustical and optical neuroimaging methods to understand the brain's neural circuitry and fundamental mechanisms. These methods have significant potential in brain-computer interfaces and clinical studies. We combine cutting-edge Electrical Engineering and Neuroimaging techniques, including single photon sensing, superconductive sensing, machine learning, FPGA design, nanoelectronics, biomedical sensing, and neuroimaging.
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The Biofilm Research Laboratory
• Bacterial biofilms
• Nanoparticles with anti-biofilm properties
• Bacterial virulence
• Bio-ethanol production -
פרופ' גיל גובס
972-3-5317390 -
ד"ר אייל גולוב
+972-3-5318072
Protein-DNA interactions and proteinbased materials
The Golub lab aims to elucidate the mechanisms that govern various aspects of nanobiotechnology and harness them to generate the next-generation of biomaterials. On the one hand, we focus on elucidating the various mechanisms that govern non-canonical DNA-protein interactions at important biological crossroads from a biophysical perspective. Derived insights could serve in the future as a solid foundation for the development of highly selective and specific ligands, both for therapeutic purposes as well as for the development of sensitive biosensors. Additionally, methods for the preparation of novel protein-based nanobiomaterials and nanoreactors are being devised based on revolutionary protein building blocks. Such materials aim to harness the structural diversity and precision that can be found in proteins with the nanosized effects that stem from nanostructures.
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Sex Determination
• 3D Genome organisation
• CRISPR genome editing
• Stem Cell Biology
• Developing in vitro systems to model the gonads -
פרופ' דורון גרבר
972-3-738-4508 -
פרופ' עמוס דניאלי
972-3-738-4653
Optical Imaging and Biosensing Laboratory
• Rapid and highly sensitive detection of biomarkers, such as proteins and specific DNA sequences
• Detection of protein-protein interactions
• Magnetic manipulation of nanoparticles, design of magnetic poles, magnetic force optimization -
פרופ' אייל הנדל
972-3-531-7316
Precise and efficient CRISPR genome editing as a curative therapy for genetic disorders
• Biotechnology
• Genetic therapy
• Genetic engineering
• Developing CRISPR technology as a method of gene therapy for genetic diseases -
פרופ' יעקב טישלר
972-3-738-4514
In the Device Spectroscopy Laboratory, we use optical spectroscopy to study nanoscale materials such as molecular organics and more generally nanostructured semiconductors, and then devices composed of these materials
• Coherent coupling in light-matter coupled systems: Organic Lasers, J-aggregates, and Polaritons.
• Ultra-high resolution scanning microcopy and spectroscopy.
• Applications of ultra-fast non-linear spectroscopy for energy sustainability.
• Novel approaches to organic crystal growth and OLED deposition -
ד"ר מורן ידיד
0543561226
Bioengineering and Regenerative Medicine
A single cardiomyocyte, micropatterned on soft silicon surface. The images demostrates two views of uptake of fluorescently labeled extracellular vesicles in the cardiomyocyte.
Image was taken by a spinning disk Olympus microscope.
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פרופ' גור יערי
972-3-738-4625
Computational Systems Immunology
• Computational
• immunology Systems biology
• Machine Learning -
פרופ' דן תומס מאיור
972-3-531-7392 -
פרופ' שולמית מיכאלי
972-3-531-8068
Mechanism and machinery of nucleolar gene silencing
• The use of nanoparticles for cytoplasmic and nuclear gene silencing
• Trans-splicing in trypanosomatids
• Protein translocation in trypanosomatids
• RNA modifications mediated by guide RNAs
• RNAi silencing in plants
• The use of nano particles as RNAi carriers into the nucleous -
פרופ' יוסי מנדל
972-3-738-4234
Ophthalmic Science and Engineering Lab
• Electro-cellular interfaces, optical and electronic micro-devices development
• Applied science for improving diagnosis, treatment and prevention of various ophthalmicdiseases.
• Artificial introduction of the visual information and its processing by the retina and the visual cortex.
• Electro-cellular interface with the autonomic system and application of high electrical field for solid tumor ablation (IRE - Irreversible Electroporation). -
פרופ' עדי סלומון
972-3-738-4235
Light-matter interaction at the nanoscale
The overall goal of my laboratory is to develop, fabricate and to use plasmonic systems as a ‘photonic environment’, or even as a ‘photonic catalyst’. In general, we aim at opening new routes for photochemical processes/reactions on surfaces by controlling the electromagnetic-field properties at the metal surface, that is, to do, 'chemistry with plasmons'.
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Theoretical and Computational Research on Polymers in Materials and Biophysics
Our research focuses on understanding the structure and dynamics of polymers through theoretical models and computational simulations. In biophysics, we study how intrinsically disordered proteins interact and examine the formation and properties of biopolymer condensates created through liquid-liquid phase separation. In materials science, we investigate how small molecules move through polymer membranes and analyze the elasticity of interpenetrating polymer networks. Throughout our research, we seek to understand the molecular mechanisms behind these phenomena and validate our findings using molecular dynamics simulations. We conduct simulations of polymer solutions, polymer assemblies, and polymer networks, and test the effects of external stimuli on these systems. Our long-term goal is to develop quantitative theories that can predict the properties of polymeric materials and that will eventually allow the rational design of new materials.
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פרופ' רחלה פופובצר
972-3-531-7509
Nanotheranostics for Personalized Medicine
• Molecular CT imaging of cancer using targeted gold nanoparticles.
• Theranostic approaches for Alzheimer’s and Parkinson’s Diseases.
• Metabolic based imaging and therapy.
• Optical/chamical imaging of enzymatic activity.
• Nanoparticle-based strategies for targeted drug delivery.
• In-vivo cell tracking techniques. -
פרופ' דרור פיקסלר
972-3-531-7598
Nano photonics, Fluorescence Imaging and Microscopy Research
• Fluorescence lifetime and anisotropy decay
• Fluorescence lifetime imaging (FLIM)
• Biological imaging based on fluorescence parameters
• Super resolution
• Light-tissue interaction -
פרופ' בינה קליסקי
972-3-738-4339
Sensitive magnetic imaging
• Superconductivity
• Nano-magnetism
• Bio-magnetism
• Scanning SQUID microscopy
• Complex oxid interfaces
• Nano-electronics -
פרופ' תומר קליסקי
972-3-738-4656
Single-cell genomics of kidney development, regeneration, and cancer
• Biochips & Sensors
• Disease Treatment
• Drug Delivery
• Genomics, Proteomics & Glycomics
• Imaging -
פרופ' שרון רוטשטיין
972-3-7384307 -
פרופ' אורית שפי
972-3-531-7079
Neuroengineering and Regeneration
• Neurobiological systems development: image processing and network analysis
• Tissue Engineering: Developing skin grafts that enable reinnervation and regeneration
• Developing devices for reagents delivery into live tissue at a microscopic resolution
• Neuroprosthetic devices: Neuron-Chip interface -
פרופ' עמוס שרוני
972-3-738-4516
Phase transitions on the nano-scale
- Spintronics
- New Temperature Coefficient of Resistance (TCR) materials
- Organic/SC hybrid
