Protein-DNA interactions and proteinbased materials

The Golub lab aims to elucidate the mechanisms that govern various aspects of nanobiotechnology and harness them to generate the next-generation of biomaterials. On the one hand, we focus on elucidating the various mechanisms that govern non-canonical DNA-protein interactions at important biological crossroads from a biophysical perspective. Derived insights could serve in the future as a solid foundation for the development of highly selective and specific ligands, both for therapeutic purposes as well as for the development of sensitive biosensors. Additionally, methods for the preparation of novel protein-based nanobiomaterials and nanoreactors are being devised based on revolutionary protein building blocks. Such materials aim to harness the structural diversity and precision that can be found in proteins with the nanosized effects that stem from nanostructures.