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Engel Hamutal

Position
Project Manager
Engel Hamutal
Telephone
Email
Hamutal.Engel@biu.ac.il
CV

2013 - 2014
Post-Doctoral Research Fellow
Mentor: Prof. Dan Thomas Major
Bar-Ilan University, Chemistry Department

2007 - 2013
Ph.D in Computational Chemistry
Thesis Advisor: Prof. Dan Thomas Major
Thesis Title: “Discretized Path Integral Methods & Nuclear Quantum Effects in Multi-dimensional Systems”
Bar-Ilan University, Chemistry Department

2004 – 2007
M.Sc. in Theoretical Chemistry
Thesis Advisor: Prof. Kenneth Kay
Thesis Title: “Global Uniform Semiclassical Approximation for Clebsch-Gordan Coefficients”
Graduated With Honors
Tel Aviv University, Chemistry Department

1999 - 2003
B.Sc. in Chemistry
Graduated With Great Honors

Publications

Hilla Vaknin, Kumudesh Mishra, Jeevitha D’Souza, Monzer Marisat, Uri Sprecher, Shane Wald-Altman, Anna Dukhovny, Yuval Raviv, Benny Da’adoosh, Hamutal Engel, Sandrine Benhamron, Keren Nitzan, Anna Permyakova, Hanna Rosenmann, Alexander Lossos, Joseph Tam, Berge A. Minassian, Or Kakhlon, Miguel Weil.A new drug candidate for glycogen storage disorders enhances glycogen catabolism: Lessons from Adult Polyglucosan Body Disease models.. bioRxiv.2021

Malak Abu-Hussien, Guru Krishnakumar Viswanathan, Lia Borisover, Michael Mimouni, Hamutal Engel, Shiri Zayit-Soudry, Ehud Gazit, Daniel Segal .Inhibition of amyloid fibrillation of γD-crystallin model peptide by the cochineal Carmine‏. International Journal of Biological Macromolecules. Volume 169, 1 February 2021, Pages 342-351

A Paul, GKK Viswanathan, A Huber, E Arad, H Engel, R Jelinek, E Gazit, ... Inhibition of tau amyloid formation and disruption of its preformed fibrils by Naphthoquinone‐Dopamine hybrid. The FEBS Journal.2021

J Ganz, T Shacham, M Kramer, M Shenkman, H Eiger, N Weinberg, ... A novel specific PERK activator reduces toxicity and extends survival in. Huntington's disease models. Scientific Reports 10 (1), 1-15.2020

SL Zada, BB Baruch, L Simhaev, H Engel, M Fridman. Chemical Modifications Reduce Auditory Cell Damage Induced by Aminoglycoside Antibiotics. Journal of the American Chemical Society 142 (6), 3077-3087. 2020

GK Viswanathan, D Shwartz, Y Losev, E Arad, C Shemesh, E Pichinuk, .Purpurin modulates Tau-derived VQIVYK fibrillization and ameliorates Alzheimer’s disease-like symptoms in animal model.... Cellular and Molecular Life Sciences 77 (14), 2795-2813. 2020

ML Bar-El, P Vaňková, A Yeheskel, L Simhaev, H Engel, P Man, Y Haitin, ... Structural basis of heterotetrameric assembly and disease mutations in the human cis-prenyltransferase complex. Nature communications 11 (1), 1-13.2020

E Pataki, LF Simhaev, H Engel, A Cohen, M Kupiec, R Weisman TOR Complex 2- independent mutations in the regulatory PIF pocket of Gad8AKT1/SGK1 define separate branches of the stress response mechanisms in fission …. PLoS genetics 16 (11), e1009196.2020

M Meli, H Engel, D Laor, E Gazit, G Colombo. Mechanisms of metabolite amyloid formation: computational studies for drug design against metabolic disorders. ACS medicinal chemistry letters 10 (4), 666-670.2019

Dana Laor, Dorin Sade, Shira Shaham-Niv, Dor Zaguri, Myra Gartner, Vasantha Basavalingappa, Avi Raveh, Edward Pichinuk, Hamutal Engel, Keita Iwasaki, Tatsuyuki Yamamoto, Hemanth Noothalapati, Ehud Gazit. Fiibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation. Nature communications 10 (1), 1-1.1..2019

E Haj, Y Losev, VG KrishnaKumar, E Pichinuk, H Engel, A Raveh, E Gazit, ... Integrating in vitro and in silico approaches to evaluate the “dual functionality” of palmatine chloride in inhibiting and disassembling Tau- derived VQIVYK peptide fibrils. Biochimica et Biophysica Acta (BBA)-General Subjects 1862 (7), 1565-1575.2018

Raphael I Benhamou, Maayan Bibi, Kfir B Steinbuch, Hamutal Engel, Maayan Levin, Yael Roichman, Judith Berman, Micha Fridman. Real-Time Imaging of the Azole Class of Antifungal Drugs in Live Candida Cells‏. ACS Chemical Biology .2017

M Dixit, H Engel, R Eitan, D Aurbach, MD Levi, M Kosa, DT Major. Classical and Quantum Modeling of Li and Na Diffusion in FePO4. The Journal of Physical Chemistry C 119 (28), 15801-15809. 2015

H Engel, R Eitan, A Azuri, DT Major. Nuclear quantum effects in chemical reactions via higher-order path- integral calculations. Chemical Physics 450, 95-101.2015

D Doron, M Weitman, A Vardi‐Kilshtain, A Azuri, H Engel, DT Major .Multiscale Quantum‐Classical Simulations of Enzymes. Israel Journal of Chemistry 54 (8‐9), 1108-1117.2014

Hamutal Engel, Asaf Azuri, Dvir Doron, Dan T Major, Higher-Order Factorization for Path-Integral Simulations of Nuclear Quantum Effects, 2013

Alexandra Vardi-Kilshtain, Dan Thomas Major, Amnon Kohen, Hamutal Engel, Dvir Doron. Hybrid quantum and classical simulations of the formate dehydrogenase catalyzed hydride transfer reaction on an accurate semiempirical potential energy surface. 2012. Journal of Chemical Theory and Computation

Hamutal Engel, Dvir Doron, Amnon Kohen, Dan Thomas Major. Momentum Distribution as a Fingerprint of Quantum Delocalization in Enzymatic Reactions: Open-Chain Path-Integral Simulations of Model Systems and the Hydride Transfer in Dihydrofolate Reductase. J. Chem. Theory Comput. 2012, 8, 4, 1223–1234

Asaf Azuri, Hamutal Engel, Dvir Doron, Dan Thomas Major. Path-Integral Calculations of Nuclear Quantum Effects in Model Systems, Small Molecules, and Enzymes via Gradient-Based Forward Corrector Algorithms. 2011. Journal of Chemical Theory and Computation

H Engel, KG Kay. Global uniform semiclassical approximation for Clebsch-Gordan coefficients. The Journal of chemical physics 128 (9), 094104.2008

Last Updated Date : 24/05/2021